Scroll through quick-bar and the chat when opened

Pause single player game

Exit the chat / command window

Clicking item or stack will move it between inventory and stack

When a container is open, Shift + clicking on an item will move up to a stack between the container and the inventory

When crafting, Shift + clicking the crafted item automatically crafts the maximum number of that item for the materials being used (up to one stack), and moves all crafted items to the inventory

In the survival inventory tab of the creative inventory, Shift + clicking the X clears the whole inventory. In any other tab, Shift + clicking an item puts a stack into the hotbar

Toggle showing extra debug information

Display Profiler graph

Reload all chunks

Reload all textures, sounds and web-loaded client resources. This is useful for resource pack makers

Toggle detailed item descriptions

Hold these keys at least for 6 seconds to trigger a manual debug crash on purpose, after the keys are released

Toggle showing hitbox around entities

Sneak

Sprint

Drop item

Drop whole stack of items. On Mac, use shortcut below, because this shortcut will quit game

(Mac) Drop whole stack of items

Hotbar slot