General (14 shortcut) # -1 W Walk Up 1 S Walk Down 1 A Walk Left 2 D Walk Right 0 ← ↑ → ← ↓ → Shoot to pressed direction 13 Space Item 0 E Bomb -3 Q Pill/Card 0 Left Ctrl (hold) Drop 3 Tab Map 18 R Restart 1 F Full screen 0 M Mute 0 P Pause
What is your favorite Binding of Isaac: Rebirth hotkey? Do you have any useful tips for it? Let other users know below.
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