Use champion's 1st ability. For abilities that target a champion, you must follow this by either left-clicking the champion or pressing F1 - F5 to target a team member. Same for W, E, and R keys

Use champion's 2nd ability

Use champion's 3rd ability

Use champion's 4th ability (Ultimate)

Add an ability point to the champion's 1st ability

Add an ability point to the champion's 2nd ability

Add an ability point to the champion's 3rd ability

Add an ability point to the champion's ultimate ability

Cast champion's 1st ability on self (must be a support spell)

Cast champion's 2nd ability on self (must be a support spell)

Cast champion's 3rd ability on self (must be a support spell)

Cast champion's ultimate ability on self (must be a support spell)

Smart cast champion's 1st ability

Smart cast champion's 2nd ability

Smart cast champion's 3rd ability

Smart cast champion's 4th ability

Attack Move (Champion moves to point, stopping to attack any enemies along the way)

Command Pet (E.g. TibbersSquare Tibbers)

Stop Command (Champion stops their current course of action)

Hold Command (Hold works like Stop, but is toggled while held down)

Cast 1st Summoner spell

Cast 2nd Summoner spell

...to 3 and 5 to 7:  Use consumable item in corresponding inventory slot

Use trinket

Recall

Close current window, such as the shop

Open champion statistics page

Toggle alert ping cursor

Toggle camera lock on champion

Center camera on champion (holding Space will hold the camera on the champion until released)

Open match stats page/leaderboard

Open match stats page/leaderboard (unlike O, the screen will disappear when the Tab button is released)

Toggle retreat ping cursor. Clicking with this hotkey on an allied champion (or their icon in the upper left area of the screen) will show an alert telling that specific champion to fall back

Cycle through minion health bar views

Turn off champion health bars

Turn off summoner names above champion health bars

Open item shop

Scroll camera in the corresponding direction

Ping location/Open Radial Menu

Retreat Ping location/Open Radial Menu

Move camera to corresponding ally champion (camera must be unlocked)

Take a screenshot

Create chat cursor

Open chat with "/all" already written

Toggle the numeric frames-per-second and latency display

Open chat history

Hold down to select or target only champions when using champion abilities or summoner spells