Scroll through quick-bar and the chat when opened

Open the menu and give back cursor control

Pause single player game

Exit the chat / command window

Toggle heads up display (HUD)

Use with F1 to take screenshots without HUD

Clicking item or stack will move it between inventory and stack

When a container is open, Shift + clicking on an item will move up to a stack between the container and the inventory

When a furnace is open, Shift + clicking an item or stack in the furnace moves it to the inventory

When crafting, Shift + clicking the crafted item automatically crafts the maximum number of that item for the materials being used (up to one stack), and moves all crafted items to the inventory

In the survival inventory tab of the creative inventory, Shift + clicking the X clears the whole inventory. In any other tab, Shift + clicking an item puts a stack into the hotbar

In the Multiplayer server selection menu, Shift + up and Shift + down moves a server name to a specific position. You can also hold shift while a server name is selected left click another server name and they will swap

Toggle showing extra debug information

Display more detailed view of the graph on the right

Display less detailed graph

Display Profiler graph

Display Help menu that lists all F3 shortcuts

Reload all chunks

Reload all textures, sounds and web-loaded client resources. This is useful for resource pack makers

Toggle the auto-pause when the window is out of focus

Toggle detailed item descriptions

Hold these keys at least for 6 seconds to trigger a manual debug crash on purpose, after the keys are released

Toggle showing hitbox around entities

Clear chat history, including previous commands

Cycle the player's game mode between Creative and Spectator

Show the chunk boundaries immediately surrounding the player

Jump

(double tap) Toggle Fly Mode in Creative mode

Sneak

Sprint

Strafe left

Strafe right

Walk backward

Walk forward

Attack / destroy

Pick block

Use item / place block

Drop item

Drop whole stack of items. On Mac, use shortcut below, because this shortcut will quit game

(Mac) Drop whole stack of items

Hotbar slot

Open Inventory. Close any open GUI

Swap items in hands

Load toolbar activator

Save toolbar activator

See the list of players

(in chat window) Cycle through possible commands or arguments and also complete player names

Open chat

Open command (open the chat window with "/" character already typed")

Advancements

Take screenshot

Toggle full screen

Toggle perspective